Hormones

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Genotropin 12mg Solution for InjectionPrescription RequiredMANUFACTURER/ MARKETERPfizer LtdSALT COMPOSITIONSomatropin (36IU)SALT SYNONYMSRecombinant human growth hormoneSTORAGEStore in a refrigerator (2 - 8°C). Do not freeze.
Genotropin 12mg Solution for Injection is a medicine that is identical to the main form of the naturally occurring human growth hormone. It is used to treat children with growth failure due to inadequate secretion of endogenous growth hormone (GH). It is used to treat short stature in adults also.

Genotropin 12mg Solution for Injection is given as an injection into the skin under the supervision of a doctor.  Your doctor or nurse will help you to learn the exact method of self-administration. You should receive appropriate training and instructions from the physician before using it. The dose and how often you take it depends on what you are taking it for. You should take this medicine for as long as it is prescribed for you.

The most common side effects of this medicine include injection site reaction, headache, and rash. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Before taking this medicine, tell your doctor if you have ever had diabetes, or have a thyroid disorder. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.  Tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You may be asked for regular monitoring of blood sugar levels, kidney function and level of growth hormone before and during the treatment.USES OF GENOTROPIN SOLUTION FOR INJECTION

• Growth failure due to growth hormone deficiency

BENEFITS OF GENOTROPIN SOLUTION FOR INJECTIONIn Growth failure due to growth hormone deficiencyGenotropin 12mg Solution for Injection acts as a replacement for growth hormone, and helps restore normal growth and development of bones and muscles in individuals suffering from growth hormone deficiency. It helps children grow taller and also enables muscle growth in both children as well as adults. However, it should be used only if prescribed by a doctor and should not be self-administered.SIDE EFFECTS OF GENOTROPIN SOLUTION FOR INJECTIONMost side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about themCommon side effects of Genotropin

• Injection site reactions (pain, swelling, redness)
• Headache
• Rash

HOW TO USE GENOTROPIN SOLUTION FOR INJECTIONYour doctor or nurse will guide you how to use this medicine.HOW GENOTROPIN SOLUTION FOR INJECTION WORKSGenotropin 12mg Solution for Injection has the same structure as natural human growth hormone which is required for the growth of bones and muscles. It also helps the fat and muscle tissues to develop in the right proportion.

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Genryzon (Somatrogon), is a medication for the treatment of growth hormone deficiency. Somatrogon is a glycosylated protein constructed from human growth hormone and a small part of human chorionic gonadotropin which is appended to both the N-terminal and C-terminal.

Genryzon (somatrogon) is a synthetic growth hormone that works by replacing the lack of growth hormone in the body. Genryzon is taken by injection just below the skin. Compared to the growth hormone GENOTROPIN^® (somatropin), its action in the body lasts longer, enabling weekly injections instead of daily. Genryzon is approved for the treatment of pediatric growth hormone deficiency (GHD) in Canada, Australia and Japan, and the EU marketing authorization is valid in all EU Member States as well as Iceland, Norway and Liechtenstein.

The next-generation long-acting recombinant human growth hormone somatrogon, is a once-weekly injection to treat children and adolescents from 3 years of age with growth disturbance due to insufficient secretion of growth hormone. Genryzon provides pediatric patients, their caregivers and healthcare providers with a new treatment option for growth hormone deficiency (GHD) that reduces the frequency of required injections from once daily to once weekly.

GHD is a rare disease characterized by the inadequate secretion of the growth hormone, somatropin, from the pituitary gland and affects one in approximately 4,000 to 10,000 children worldwide. The disease can be caused by genetic mutations or acquired after birth. Without treatment, affected children will have persistent growth attenuation and a very short height in adulthood, and puberty may be delayed.Children may also experience other problems with physical health and mental well-being.

The safety and efficacy of Genryzon (somatrogon) was demonstrated in a randomized, open-label, active-controlled Phase 3 study conducted in over 20 countries. In this study, 224 prepubertal, treatment-naïve children with growth hormone deficiency (GHD) were randomized 1:1 to receive NGENLA once-weekly or GENOTROPIN^® (somatropin) once-daily. The study met its primary endpoint of Genryzon non-inferiority compared to GENOTROPIN, as measured by annual height velocity at 12 months. Genryzon was generally well tolerated in the study and had a safety profile comparable to GENOTROPIN. Participants had the opportunity to enroll in a global, open-label, multicenter, long-term extension study in which they were able to either continue receiving or switch to Genryzon. Approximately 95% of the patients switched into the open-label extension study and received Genryzon treatment.